|
KMID : 0369819910210010051
|
|
Jorunal of Korean Pharmaceutical Sciences
1991 Volume.21 No. 1 p.51 ~ p.55
|
|
|
The Entrapment of Vitamin E Acetate in Porous Spheres
|
|
양윤정/Yang YJ
배봉진/이규식/전인구/Bae BJ/Lee KS/Chun IK
|
|
|
Abstract
|
|
|
|
Porous spheres composed of natural waxes and inorganic materials containing vitamin E acetate as a drug were prepared by impregnation method. Furthermore, the amount of vitamin E acetate entrapped in the spheres and the release rate of vitamin E acetate from the spheres were studied. The impregnation of vitamin E acetate was carried out by dipping the spheres in vitamin E acetate solutions. Entrapment mechanism of vitamin E acetate could be expressed in terms of Langmuir's adsorption isotherm. The amount of vitamin E acetate entrapped in porous spheres was influenced by the structure and concentration of the polymer used in vitamin E acetate solutions, and the concentration of vitamin E acetate. Release characteristics of vitamin E acetate from the spheres were investigated by withdrawing samples periodically and analyzing them by spectrophotomer.
|
|
|
KEYWORD
|
|
|
porous sphere, vitamin E acetate, entrapment, release characteristics, kinetic analysis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|